Shaun J. Grannis, M.D.

Associate Director, Center for Biomedical Informatics, Regenstrief Institute, Inc. and Assistant Professor of Family Medicine

Area of Interest/Specialty:
Medical Informatics



Medical School: Michigan State University College of Human Medicine

Residency: MidMichigan Family Practice Residency Program

Fellowship: Indiana University, The Regenstrief Institute, National Library of Medicine Medical Informatics Fellowship


Professional Organizations:

American Academy of Family Practice, 1997-present

American Medical Informatics Association, Member, 1999-present

American Board of Family Practice, Diplomat, 2000-present

International Society for Disease Surveillance, 2006-present

Fellow of the American College of Medical Informatics (ACMI), 2012-present



1st Place, Student Paper Competition, 2002

The Martin Epstein Award for "outstanding contribution to the Medical Informatics Body of Knowledge," AMIA Fall Symposium, 2002

The eHI Blueprint Award for Improving Population Health for "an outstanding example of a biosurveillance system that leverages health information exchange to identify early disease indicators to detect outbreaks before definitive diagnoses are made," e-Health Initiative conference, 2007

Distinguished Paper Award, American Medical Informatics Association Fall Symposium, 2011

Outstanding Research Article in Biosurveillance, International Society for Disease Surveillance, 2011

Fall Symposium Award for "Best of AMIA in Public Health Informatics, The American Medical Informatics Association, 2012

Research Frontiers Trailblazer Award, Indiana University Purdue University Indianapolis, 2013

Federal Grants (awarded)


Principal Investigator

Syndromic Surveillance Data Exchange and Analysis
National Library of Medicine
09/2003 – 08/2007

Public Health Emergency Surveillance System
CDC / Indiana State Department of Health
7/2004 – 8/2009

Accelerating Public Health Situational Awareness through Health Information Exchanges
Centers for Disease Control
J. Marc Overhage (Co-PI)
2/2008 – 11/2009

Indiana Center of Excellence for Public Health Informatics (ICEPHI)
Centers for Disease Control
9/2009 – 8/2014

Advancing Patient Identity Management in the Context of Real-World Health Information Exchange
Agency for Healthcare Research and Quality
9/2009 – 7/2013

Public Health Emergency Surveillance System
CDC / Indiana State Department of Health
8/2010 – 8/2011

Improving Population Health through Enhanced Targeted Regional Decision Support
Agency for Healthcare Research and Quality
9/2011 – 8/2016


An Evolving Statewide Indiana Information Infrastructure
Agency for Healthcare Research and Quality
J. Marc Overhage (PI)
9/2004 – 8/2009

A Center of Excellence in Medical Informatics to Provide an Advanced Infrastructure for Human Research: A Catalyst for Indiana Research
Indiana 21st Century Technology & Research Fund
Paul Dexter (PI)
8/2004 – 8/2008

Health Information Technology Resource Center
Agency for Healthcare Research and Quality/NORC
Julie McGowan (PI)
9/2004 – 9/2009

National Visualization and Analytics Center
Department of Homeland Security/Purdue
David S. Ebert (PI)
1/2006 – 12/2008

Adaptive Turnaround Documents to Link Newborn Screening Programs to Medical Home
Health Resources and Services Administration
Steven Downs (PI)
6/2006 – 5/2008

Nationwide Health Information Network Trial Implementation
Department of Health and Human Services/Office of the National Coordinator
J. Marc Overhage (PI)
9/2007 – 1/2009

An East African Center of Excellence for Informatics Training
NIH-Fogarty International Center
Paul Biondich (PI)
9/2009 – 6/2014

Health Informatics Public Private Partnership
Paul Biondich (PI)
10/2009 – 03/2015

Agency for Healthcare Research and Quality
Paul Dexter (PI)
9/2010 – 9/2013

Enhancing Regional Infrastructures for Early Case Capture of Pediatric and Young Adult Cancer Cases – Phase 1
Centers for Disease Control
Eric Durbin (PI)
10/2011 – 9/2014

MCPHD Refugee Health Surveillance
Centers for Disease Control
Shandy Dearth (PI)
9/2012 – 9/2017

BIGDATA: Small: DCM:DA: Innovative Automated Data Quality Analytics Using Realworld, Large-scale Health Data
National Science Foundation
Kris Hauser (PI)
01/2014 – 12/2016

Improving Vaccine-Preventable Disease Reporting and Surveillance through Health Information Exchange
Robert Wood Johnson Foundation
Brian Dixon (PI)
01/2013 – 12/2015

Evidence-Based Medicine Learning and Application: A Blended Model of E-learning and In-class Activities to Teach Evidence-Based Medicine and Enhance Patients' Quality of Care
Indiana University
Morhaf Achkar (PI)
05/2014 – 04/2016

Enhancing Regional Infrastructures for Early Case Capture of Pediatric and Young Adult Cancer Cases – Phase 2
Centers for Disease Control
Eric Durbin (PI)
10/2014 – 9/2018

The HIV Care Continuum Among Recent Offenders
National Institute of Health
Sara Wiehi (PI)
01/2015 – 12/2018

Search PubMed for Dr. Grannis' articles


Selected Publications:

  • Finnell JT, Overhage JM, Grannis SJ. All Health Care is Not Local: An Evaluation of the Distribution of Emergency Department Care Delivered in Indiana. AMIA Annu Symp Proc. 2011:409-16.
  • Grannis S, Vreeman D. A vision of the journey ahead: using public health notifiable condition mapping to illustrate the need to maintain value sets. AMIA Annu Symp Proc. 2010 Nov 13;2010:261-5. PubMed PMID: 21346981
  • Daggy JK, Xu H, Hui SL, Gamache RE, Grannis SJ. A practical approach for incorporating dependence among fields in probabilistic record linkage. BMC Medical Informatics and Decision Making 2013;13:97. doi:10.1186/1472-6947-13-97.
  • Gichoya J, Dixon B, Finnell JT, Vreeman D, Gamache R, Grannis S. An Evaluation of the Rates of Repeat Notifiable Disease Reporting and Patient Crossover Using a Health Information Exchange-based Automated Electronic Laboratory Reporting System. AMIA Annu Symp Proc. 2012:1229-36.
  • Grannis SJ, Overhage JM, McDonald CJ. Analysis of identifier performance using a deterministic linkage algorithm. Proc AMIA Symp. 2002:305-9. PubMed PMID: 12463836. (first author)
  • Grannis SJ, Overhage JM, Hui S, McDonald CJ. Analysis of a probabilistic record linkage technique without human review. AMIA Annu Symp Proc. 2003:259-63.  PubMed PMID: 14728174 (first author)
  • Grannis SJ, Overhage JM, McDonald C. Real world performance of approximate string comparators for use in patient matching. Stud Health Technol Inform. 2004;107(Pt 1):43-7. PubMed PMID: 15360771. (first author)
  • Dixon BE, Grannis SJ, Revere D. Measuring the impact of a health information exchange intervention on provider-based notifiable disease reporting using mixed methods: a study protocol. BMC Medical Informatics and Decision Making 2013; 13:121.
  • Dixon BE, Gibson PJ, Grannis SJ. Estimating increased electronic laboratory reporting volumes for meaningful use: Implications for the public health workforce. Online Journal of Public Health Informatics. 2014;5(3) :e225.
  • Dixon BE, Vreeman DJ, Grannis SJ. The long road to semantic interoperability in support of public health: Experiences from two states. Journal of Biomedical Informatics. 2014. In press.

Selected Presentations:

  • Grannis S. Delivery of Automated Notifiable Condition Reports: A Success Story of the Regenstrief Institute's Notifiable Condition Detector. Invited lecture for the CDC National Center for Public Health Informatics Integrated Surveillance Seminar Series, Atlanta, GA, 12/2008.
  • Grannis S. Anonymization and the HIPAA Privacy Rule. Invited Panelist for the Workshop on the HIPAA Privacy Rule's De-Identification Standard. Washington, DC. March 3/2010.
  • Grannis S. An Overview of Indiana Network for Patient Care's (INPC) Federated Data Model supporting Health Information Exchange. Invited Panelist for the International Society of Pharmicoepidemiology 2010 Mid-Year Conference. Raleigh, North Carolina. April 12/2010.
  • Grannis S. An Overview of the state of Health Information Exchange in the United States and Critical Next Steps. Presented at the National Health Policy Forum's roundtable on health information exchange. Washington, DC. 5/2013.
  • Grannis S. Biomedical Informatics: A View of Where We've Been and Where We're Going. Presented at the University of Kentucky Division of Biomedical Informatics Seminar Series. Lexington, KY. 1/2014
  • Grannis S. Obstacles to Adding Measures to EHRs and Ways to Overcome these for the Patient, Provider, System, and Society: General Principles and Real-World Experience. Presented to the Institute of Medicine Committee on Recommended Social and Behavioral Domains and Measures for Electronic Health Records. Washington, DC. 4/2014
  • Grannis S. Data Aggregation, Liquidity, and the Learning Healthcare System: Perspectives from the Indiana Experience. Presented at the University of Utah Biomedical Informatics Department Seminar. Salt Lake City, UT. 4/2014.
  • Grannis S. OpenHIE: Helping Underserved Environments Better Leverage Their Electronic Health Information Through Standardization. Presented at the CDC Public Health Informatics Conference. Atlanta, GA. 4/2014.
  • Grannis S. Enhancing Early Capture of Population-Based Cancer Surveillance Data through Inter-State Health Information Exchange. Co-presented at the CDC Public Health Informatics Conference with Dr. Eric Durbin of the University of Kentucky. Atlanta, GA. 4/2014.
  • Grannis S. A Methodology and Real-world Examples Leveraging Open Source Technology to Support Public Health Person Identity Management. Presented at the CDC Public Health Informatics Conference. Atlanta, GA. 5/ 2014.

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